Clarke Quay was named after Sir Andrew Clarke, Singapore's second Governor and Governor of the Straits Settlements from 1873 to 1875, who played a key role in positioning Singapore as the main port for the Malay states of Perak, Selangor and Sungei Ujong.

Clarke Quay is also the name of a road along the quay, part of which has since been converted into a pedestrian mall. Clarke Street, located next to Clarke Quay, was officially named in 1896, and was originally two streets known simply as East Street and West Street in north Kampong Malacca. Similar to Clarke Quay, Clarke Street has since been converted into a pedestrian mall.